Microsoft recommends that you complete the security tasks listed in the following table to fully secure your Microsoft Office, Azure and Hosted Exchange Data.
Items 1,4,5,6 needs to be carried out by your Office 365 Mail Administrator.
Item 2 needs to be carried out in-house and as a user training exercise.
Item 7,8,9 require the purchase of Microsoft Advance Threat Protection (ATP) for each user unless you are using Office 365 Enterprise E5 which has ATP already built in. Your Office 365 Mail Administrator can arrange the purchase and installation.
See also https://docs.microsoft.com/en-us/office365/securitycompliance/security-best-practices
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